THE HISTOPATHOLOGICAL CHANGES IN LIVER TISSUE FOLLOWING INJECTION WITH ANTIBIOTIC-RESISTANT PSEUDOMONAS AERUGINOSA

  • Faiza Jabbar Joda Ministry of Education, Open College of Education, Iraq
DOI: https://doi.org/10.69980/bs.v12i1.6696
Keywords: P. aeruginosa, antibiotic-resistant, histopathological, liver, Kirby Bauer method

Abstract

The study was aimed to investigated the e histopathological changes in liver tissue following infection with antibiotic-resistant Pseudomonas aeruginosa, material and method  P . aeruginosa was antibiotic-resistant P. aeruginosa from  Al-Mustansiriyah University, College of Science, Microbiology Laboratory.  The antibiotic susceptibilityfor pathogens was determined using the Kirby Bauer method , the used antibiotcs are  Netilmicin (Net), Ofloxacin (OF), Meropenem (MEM), Chloramphenicol (C), Ciprofloxacin (CIP), Levofloxacin (LE), Tobramycin (TOB) , Amikacin (AK), Norfloxacin (NOR), Cefuroxime (CXM), Cefepime (CPM), Cefoxitin (FOX), Nalidixic acid (NA), and Gentamicin (CN) ة Tetracycline (TE) for in vivo study  the study was included two groups each group contain 10 male rats   Group 1:  The animals were administered distilled water and served as control.  Group 2 : all animal were injected by Intraperitoneal injection with 1×108 CFU/mL of P. aeruginosa .Results  Pseudomonas aeruginosa isolate demonstrated extensive resistance to entire used antibiotics  the histological examination showed  Group 1 the liver was normal as  normally hepatocytes & normal sinusoid with normal central vein normal portal triad and  normally arrangement of cords While the group 2 of liver severe necrosis with atrophy of hepatic cords and disaagrngment of hepatic cords & severe dilation of sinusoids & damage of vascular tunica and severe necrosis with atrophy of hepatic cords and disaagrngment of hepatic cords. Conclusion P. aeruginosa effects of on tissues are closely linked to their resistance to antibiotics. Based on the histological analysis of liver sections, this conclusion was reached in the current investigation.

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Published
2026-05-20
How to Cite
Faiza Jabbar Joda. (2026). THE HISTOPATHOLOGICAL CHANGES IN LIVER TISSUE FOLLOWING INJECTION WITH ANTIBIOTIC-RESISTANT PSEUDOMONAS AERUGINOSA. IJRDO - JOURNAL OF BIOLOGICAL SCIENCE, 12(1), 22-26. https://doi.org/10.69980/bs.v12i1.6696
Issue
Vol. 12 No. 1 (2026): IJRDO - JOURNAL OF BIOLOGICAL SCIENCE (ISSN: 2455-7676)
Section
Articles

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