ASSESSMENT OF LAMBDA-CYHALOTHRIN BIOACCUMULATION IN CYPRINUS CARPIO AND ITS ECOTOXICOLOGICAL SIGNIFICANCE
Abstract
Lambda-cyhalothrin is a commonly utilized synthetic pyrethroid insecticide that has known aquatic organism toxicity, but little evidence exists supporting its bioaccumulation with genetic damage in fish especially Cyprinus carpio. The ecotoxicological effects of lambda-cyhalothrin on freshwater fish were evaluated based on data retrieved from the U.S. EPA ECOTOX Knowledgebase under the headings of biological effects, tissue-specific responses, genetic effects, exposure duration and bioaccumulation. The fish-result data set comprised 465 fish-result records, most of which were for mortality, biochemical alterations, enzyme-related effects, and genetic responses. Of these, 75 were deemed as genetic effects (DNA damage, micronuclei and nuclear abnormalities, as well as other mitotic changes). Genetic response was reported after several hours up to 192 h (8 days), and liver, erythrocytes, brain, gills, muscle and kidney were the main response sites. There were only two records of direct bioaccumulation, 674.3 and 620.6 L/kg, for Danio rerio. The records included a total of ~48 h of exposure and 72 h of observation, which would show measurable short-term bioconcentration. There was no direct ECOTOX record relating the exposure to lambda-cyhalothrin, bioaccumulation and/or DNA damage in the Comet-assay test for C. carpio. The results indicate a lack of species-specific knowledge and stress the need to undertake common-carp studies that combine tissue-residue analysis, BCF/BAF estimation, exposure-duration assessment, and standardized endpoints for genotoxicity to facilitate improved ecological risk assessment.
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2.Arshad, S. M., Ghayyur, S., Ullah, R., Khan, M. F., Samad, S. U., & Ghayyur, S. (2026). Multivariate assessment of sublethal Panadol Extra toxicity in Cyprinus carpio using hemato-biochemical and genotoxic markers. Comparative Clinical Pathology, 35(1), 33.
3.Banaee, M., Oryan, A., Gholamhosseini, A., Multisanti, C. R., & Faggio, C. (2026). Evaluation of Detoxification‐Related Gene Expression, Oxidative Stress Biomarkers, and Blood Biochemical Parameters in Common Carp (Cyprinus carpio) Co‐Exposed to Polyethylene Microplastics and Deltamethrin. Journal of Applied Toxicology.
4.Banaei, M., Foroozanfar, M., & Jafarinia, M. (2022). Evaluation of blood biochemical parameters and oxidative stress biomarkers in common carp (Cyprinus carpio) exposed to deltamethrin.
5.Barathinivas, A., Ramya, S., Neethirajan, K., Jayakumararaj, R., Pothiraj, C., Balaji, P., & Faggio, C. (2022). Ecotoxicological effects of pesticides on hematological parameters and oxidative enzymes in freshwater Catfish, Mystus keletius. Sustainability, 14(15), 9529.
6.Behera, B. C., Behera, B., Udgata, S. K., Sahoo, R., Pattnaik, S., Mohanty, B., & Padhan, S. (2026). Assessment of Lambda‐Cyhalothrin Toxicity on Haematological, Biochemical and Histopathological Parameters in Freshwater Fish Labeo rohita. Journal of Applied Toxicology.
7.Burch, E., Hussein, M. A., Zaki, M., Kamal, L. T., Zaki, G., Shoeib, T., ... & Abdelnaser, A. (2025). Assessing the effects of pesticides on aquacultured fish and ecosystems: A comprehensive environmental health review. Fishes, 10(5), 223.
8.El-Bouhy, Z. M., Mohamed, F. A., Elashhab, M. W., & El-Houseiny, W. (2023). Toxicity bioassay and sub-lethal effects of profenofos-based insecticide on behavior, biochemical, hematological, and histopathological responses in Grass carp (Ctenopharyngodon idella). Ecotoxicology, 32(2), 196-210.
9.Ghosh, A. K., & Sarower, M. G. (2024). Potential toxicity of pesticides and its transformation products to aquatic organisms. Khulna University Studies, 21-32.
10.Hazarika, H., Laskar, M. A., Krishnatreyya, H., Islam, J., Kumar, M., Zaman, K., ... & Chattopadhyay, P. (2024). Bioaccumulation of deltamethrin and piperonyl butoxide in Labeo Rohita fish. Ecotoxicology and Environmental Safety, 284, 116908.
11.Huang, X., Wang, A., Luo, J., Gao, Y., Guan, L., Zhang, P., ... & Li, B. (2022). Lambda-cyhalothrin-loaded nanocapsules pose an unacceptable acute toxicological risk to zebrafish (Danio rerio) at the adult and larval stages but present an acceptable risk to embryos. Journal of hazardous materials, 422, 126853.
12.Iqbal, K., Sohail, M., Hussain Rind, K., & Habib, S. S. (2025). Agrochemical contamination and fis
13.Jiang, J., He, B., Wei, Y., Cui, J., Zhang, Q., Liu, X., ... & Zhou, Z. (2022). The toxic effects of combined exposure of chlorpyrifos and p, p’-DDE to zebrafish (Danio rerio) and tissue bioaccumulation. Aquatic Toxicology, 248, 106194.
14.Jindal, R., Sharma, R., Kaur, P., Kaur, S., Multisanti, C. R., & Faggio, C. (2024). Mitigation of haemato-genotoxic and stress response effects in Cyprinus carpio via silymarin dietary supplementation following deltamethrin exposure. Heliyon, 10(7).
15.Korkmaz, N. (2024). Toxic and histopathological effects induced by exposure to the pesticide dicamba in carp Cyprinus carpio L. Environmental Science and Pollution Research, 31(57), 65790-65803.
16.Kumar, M., Singh, V., Narain, G. P., Dubey, A., Yadav, S., Jain, A., & Singh, S. (2025). Acute exposure of Cypermethrin and Malathion induces genotoxicity, hematological, and histopathological alterations in snakehead murrel, Channa punctata. Chemistry and Ecology, 41(8), 1090-1114.
17.Martins-Gomes, C., Coutinho, T. E., Silva, T. L., Andreani, T., & Silva, A. M. (2022). Neurotoxicity assessment of four different pesticides using in vitro enzymatic inhibition assays. Toxics, 10(8), 448.
18.Moghadam, M. J. P., Oujifard, A., Davoodi, R., & Hosseini, A. (2023). Evaluation of hematology and biochemistry of Cyprinus carpio juveniles exposed to NeemAzal biopesticide: acute and sub-chronic toxicity study. Journal of Fisheries and Environment, 47(2), 47-57.
19.Noreen, S., Khan, I. M., Khan, M. S., Zarnaab, B., Gul, I., Khan, M. Z., ... & Liu, Y. (2023). Comparative valuation of the chlorpyrifos, acetamiprid, and lambda-cyhalothrin toxicity and their hematological and histopathological consequences in pigeons. Environmental Science and Pollution Research, 30(40), 92817-92829.
20.Pokhrel, H., Sarmah, R., Sharma, D., Ingtipi, L., Ahmed, N., Bhagabati, S. K., ... & Bordoloi, B. (2025). Integrated biomarker response in common carp fingerlings exposed to neonicotinoid insecticide imidacloprid. Ecotoxicology, 34(8), 1516-1536.
21.Sebastião, M. V. R., Obando, J. M. C., da Silva Nascimento, D., Carolino, A. H., de Souza Silva, G., Pellis, B., ... & Sanches, A. L. M. (2025). Ecotoxicological assessment of pesticide mixtures: effects of imidacloprid and propiconazole on Danio rerio and Astyanax lacustris. Aquatic Toxicology, 107544.
22.Sohail, M. (2025). Fish as Bioindicators of Pesticide-Induced Histological and Biochemical Toxicity. International Journal of Forest Sciences, 2, 205-215.
23.TESSI, D. R. Y. (2023, March). Toxic effects of lambda-cyhalothrin and acetamiprid on freshwater mussels.
24.Tufail, F., Tanvir, F., Irfan, A., Javed, I., Bilal, A., Iftikhar, A., ... & Shoukat, S. (2025). Histopathological assessment of pesticide exposure on tilapia fish: implications for health monitoring and environmental risk assessment. Policy Res J, 3(6).
25.Turan, F., & Ergenler, A. (2022). Investigation of the genotoxic effect of acetamiprid in Cyprinus carpio using the micronucleus analysis and the comet assay. Turkish Journal of Maritime and Marine Sciences, 8(2), 80-89.
26.U.S. Environmental Protection Agency. (2026). ECOTOX Knowledgebase [Data set]. U.S. Environmental Protection Agency. https://cfpub.epa.gov/ecotox/.
27.Yaseen, M., Ullah, H., Mubarik, M., Jadoon, W. A., Ghayyur, S., Iftikhar, M., & Ghayyur, S. (2025). Evaluating pesticide-induced toxicity in Cyprinus carpio using hemato-biochemical biomarkers. Ecotoxicology, 34(8), 1489-1505.
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